Up to now, treatment of diabetic polyneuropathy remains unsatisfactory. Nev
ertheless, new pathogenetic concepts about the possible reasons for the dev
elopment of diabetic neuropathy create new therapeutic approaches to the di
sease. The following article reviews the therapeutic agents commonly used.
Furthermore some new substances are reported which interfere in the pathoge
netic pathway of diabetic neuropathy and might be beneficial for the patien
ts suffering from this neuropathy in the future.