The authors treated a 38-year-old man with nanophthalmic uveal effusio
n with scleral windows and local application of mitomycin-C. The patie
nt underwent two separate surgical procedures, involving placement of
scleral windows in all four quadrants and topical application of mitom
ycin-C in one quadrant. Episcleral scarring led to closure of scleral
windows in all quadrants except one quadrant where mitomycin-C was app
lied during the first surgery. The uveal effusion resolved following t
he second surgery. No complications related to mitomycin-C were observ
ed. Topical mitomycin-C may be a useful adjunct in the surgical manage
ment of uveal effusion syndrome.