Tangential foveal traction by the posterior vitreous cortex is regarde
d as the main cause of full-thickness macular holes. This report docum
ents two cases of full-thickness macular holes that developed after vi
trectomy for other diseases in the apparent absence of the cortical vi
treous traction. Autologous serum with pars plana vitrectomy was used
to treat these cases. Anatomic closure of the holes was achieved. Macu
lar holes developing after vitrectomy may have an etiology other than
tangential vitreous traction, and secondary vitrectomy is useful in tr
eating such holes.