Estrogen dependency in uterine endometrial cancers

Estrogen dependency in uterine endometrial cancers involves complicated tum or biology. A transformed phenotype of uterine endometrial cancers is suppo rted by estrogen-dependent oncogene (c-Ha-rns, c-fos and c-jun) expressions . The relative overexpression of estrogen receptor exon 5 splicing variant and the damaged expression of progesterone receptor A, which belong to a la ck of estrogen dependency, are related to metastatic potential. The estroge n-related metastatic processes, detachment, invasion and angiogenesis in so me uterine endometrial cancers can be inhibited by progestins.