Two cases of adult Still's disease with severe hepatic manifestations
are reported. One was a 22-year-old man who developed abdominal pain a
nd hepatic failure during the first bout of adult Still's disease. The
other was a 23-year-old man who had severe cytolysis and jaundice dur
ing a recurrence of juvenile-onset Still's disease. Twelve similar cas
es have been reported in the literature between 1971 and 1975, with a
fatal outcome in four cases. Hepatic manifestations during adult Still
's disease can be spontaneous or related to a drug, a liver infection,
or a hemophagocytic syndrome.