A new bioactive norquinone-methide triterpene from Maytenus scutioides

Authors
Gonzalez, AG Alvarenga, NL Bazzocchi, IL Ravelo, AG Moujir, L
Citation
Ag. Gonzalez et al., A new bioactive norquinone-methide triterpene from Maytenus scutioides, PLANTA MED, 64(8), 1998, pp. 769-771
Citations number
11
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
64
Issue
8
Year of publication
1998
Pages
769 - 771
Database
ISI
SICI code
0032-0943(199812)64:8<769:ANBNTF>2.0.ZU;2-0
Abstract
By antimicrobial and cytotoxic-guided fractionation, a bioactive norquinone -methide triterpene, 15 alpha-hydroxypristimerin, was isolated from a South American medicinal plant, Maytenus scutioides. Its structure was determine d on the basis of spectroscopic evidence. Successful chemical transformatio n of pristimerin to netzahualcoyene indicates that the 15-hydroxy compounds seems to be a possible precursor of 14(15)-ene-quinone-methide-triterpenoi ds in the biogenetic pathway.