The application of Ir-complexes of trans-2,5-dialkylpyrrolidinyl-benzyldiphenylphosphines to the enantioselective reduction of imines

Authors
Cahill, JP Lightfoot, AP Goddard, R Rust, J Guiry, PJ
Citation
Jp. Cahill et al., The application of Ir-complexes of trans-2,5-dialkylpyrrolidinyl-benzyldiphenylphosphines to the enantioselective reduction of imines, TETRAHEDR-A, 9(24), 1998, pp. 4307-4312
Citations number
31
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
9
Issue
24
Year of publication
1998
Pages
4307 - 4312
Database
ISI
SICI code
0957-4166(199812)9:24<4307:TAOIOT>2.0.ZU;2-S
Abstract
The preparation of iridium (COD) complexes of phosphinamine ligands possess ing an enantiopure trans-2,5-dialkylpyrrolidinyl unit is described. These c omplexes were successfully applied to the enantioselective reduction of tes t substrate imines in excellent conversions with enantioselectivities of up to 52% ee. In attempts to optimize reaction conditions the catalyst loadin g, time, and hydrogen pressure were varied. X-Ray crystal structures of the iridium (COD) tetrafluoroborate complexes 5 and 6 are discussed. (C) 1998 Elsevier Science Ltd. All rights reserved.