Localization of human endopeptidase EC 3.4.24.15 (THOP1) to chromosome 19p13.3

The human endopeptidase EC 3.4.24.15, also known as thimet oligopeptidase 1 (THOP1) is shown to be localized on chromosome 19p13.3 using the human cDN A for THOP1. The cDNA was hybridized against the cosmid contig map of chrom osome 19 generated by the Lawrence Livermore National Laboratory. The resul ts were confirmed by fluorescent in situ hybridization and Southern and dot blot analyses. This localization shows that the gene for THOP1 is not in t he same region as the Apolipoprotein E gene, which is on the q-arm of chrom osome 19 at 13.3, and that the potential influence of THOP1 in Alzheimer's disease is not dependent upon this locus.