Expansile bone lesions in a three-generation family

We report on a three-generation family with "expansile" bone lesions of the distal radius and ulna, cortical thickening of the proximal long bones, an d pathologic fractures. The differential diagnosis of expansile bone lesion s includes isolated bone cysts and tumors, such as enchondromas and fibrous dysplasia; familial expansile osteolysis; and the genochondromatoses. Our patients have findings most similar to the genochondromatoses; however, the distribution of the lesions and the accompanying manifestations may be evi dence for a unique genetic condition in this family. (C) 1999 Wiley-Liss, I nc.