Jp. Granger et al., Role of nitric oxide in modulating renal function and arterial pressure during chronic aldosterone excess, AM J P-REG, 45(1), 1999, pp. R197-R202
Citations number
38
Categorie Soggetti
Physiology
Journal title
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
Chronic aldosterone (Aldo) excess is associated with transient sodium reten
tion, extracellular fluid volume expansion, renal vasodilation, and hyperte
nsion. The purpose of this study was to determine the role of nitric oxide
(NO) in mediating the renal vasodilation and the escape from the sodium-ret
aining actions of Aldo. To achieve this goal, we examined the long-term eff
ects of Aldo (15 mu g.kg(-1).min(-1) for 7 days) in conscious, chronically
instrumented control dogs (n = 9) and in dogs (n = 12) pretreated with the
NO synthesis inhibitor NG-nitro-L-arginine methyl ester (L-NAME; 10 mu g.kg
(-1).min(-1)). In control dogs, Aldo caused a transient sodium retention (1
26 +/- 6 to 56 +/- 2 meq/day) followed by a return of sodium excretion to n
ormal levels. Aldo also increased renal plasma flow by 15% (205 +/- 13 to 2
33 +/- 16 ml/min), glomerular filtration rate by 20% (72 +/- 3 to 87 +/- 5
ml/min), and arterial pressure from 90 +/- 3 to 102 +/- 3 mmHg. Aldo increa
sed urinary nitrate/nitrite excretion by 60% in the control dogs. Although
the sodium-retaining (144 +/- 7 to 56 +/- 7 meq/day) and arterial pressure
(122 +/- 6 to 136 +/- 5 mmHg) responses to Aldo were the same in dogs pretr
eated with L-NAME compared with control, the renal hemodynamic response was
markedly attenuated. The results of this study suggest that NO plays an im
portant role in mediating the renal vasodilation during chronic Aldo excess
.