Gene transfer approaches offer the promise of revolutionizing medicine. in
this review, we focus on the current and future prospects of somatic gene t
ransfer into the kidney. The advantages and disadvantages of current vector
systems are described, and the ex vivo and in vitro approaches applicable
to the kidney are reviewed. We discuss uses of gene transfer approaches to
dissect the pathogenesis of kidney disease and the future directions and ap
plications of gene transfer to combat kidney destruction.