Lymphomatoid granulomatosis of the lung: A clinico-pathological study

Lymphomatoid granulomatosis is the only form of pulmonary angiitis histolog ically characterized by a necrotizing angiocentric and angiodestructive lym phoid infiltrate, with an admixed T-cell reaction. We evaluated three patie nts with a single lung nodule not diagnosed by routine radiological and end oscopic assays. Our investigations showed a prevalence of T-cells in areas of diffuse infiltration, which were actively replacing reaction follicular areas of B-cells, similarly to T-cell lymphomas. Further pathologic assays suggested the histologic diagnosis of grade I lymphomatoid granulomatosis f or all three evaluated specimens. After two years, patients treated with a combination of surgical resection and chemotherapy were disease free, suppo rting the efficacy of aggressive therapy in the management of this often mi streated group of lymphoid proliferations.