Nm23-H1 protein, DNA-ploidy and S-phase fraction in relation to overall survival and disease free survival in transitional cell carcinoma of the bladder
M. Alderisio et al., Nm23-H1 protein, DNA-ploidy and S-phase fraction in relation to overall survival and disease free survival in transitional cell carcinoma of the bladder, ANTICANC R, 18(6A), 1998, pp. 4225-4230
Objectives: To explain the overall survival (OS) and disease free survival
(DFS) in relation to nm23-H1 protein, DNA-ploidy and S-phase fraction (SPF)
in transitional cell carcinoma of the bladder. Patients and methods: Ninet
y-four samples were obtained from patients with transitional cell carcinoma
of the bladder examined between 1994 and 1996. The patients were underwent
cistectomy or surgical biopsy and the material was histologically evaluate
d according to World Health Organization classification. Nm23-H1 protein ex
pression in immunohistological staining and DNA ploidy S-phase fraction by
flow cytometric were performed Results: the correlation between OS and stag
ing, grading, DNA-ploidy and S- phase was significant; whereas the overall
survival and nm23-H1 protein, was not significant. The relationship between
DFS and stage, DNA-ploidy and S-phase had a significant value. The correla
tion between DFS and age, sex, grading and nm23-H1 protein was not signific
ant. There was no significant difference in age, sex, stage, grading, DNA-p
loidy and SPF distribution between patients with nm23-H1 positive bladder c
ancer and those with nm23-H1 negative tumours. Conclusion: in our study, mu
ltivariate analysis showed that stage, ploidy and SPF were the strongest pr
ognostic factors in predicting disease-free survival and prolonged survival
, while nm23-H1 expression was not related to disease progression and/or pr
olonged survival. This expression, therefore, does not appear to be an inde
pendent prognostic factor in bladder cancer, although a still larger number
of patients and a longer follow-up period are now needed for a definitive
assessment of the prognostic significance of nm23-H1 expression.