Characteristic spectral studies and in vitro antimicrobial and in vivo multi-infection antifungal activities in mice of new organotin(IV) derivativesof heterocyclic amino acids
M. Nath et al., Characteristic spectral studies and in vitro antimicrobial and in vivo multi-infection antifungal activities in mice of new organotin(IV) derivativesof heterocyclic amino acids, APPL ORGAN, 13(1), 1999, pp. 29-37
The nature of the products obtained on reacting R3SnCl (R=Me, Bu and Ph), P
h2SnCl2 and Bu2SnO with amino acids having nitrogen-containing heterocyclic
rings; i.e. L-histidine and DL-tryptophan, is shown to depend upon the rea
ction conditions. Ten new organotin(IV) derivatives of these amino acids ha
ve been synthesized and characterized by elemental analyses, molar conducta
nce and electronic spectra, and the bonding in these complexes is discussed
in terms of their infrared, far-infrared,H-1 and C-13 NMR, and Sn-119 Moss
bauer spectra, The complexes soluble in DMSO have been tested in vitro agai
nst a wide spectrum of bacteria and fungi and found to be active. Two compl
exes, Ph3SnL-1 and Ph3SnL-2, have been found to be slightly active in vivo
against a multi-infection fungal model in mice. Copyright (C) 1999 John Wil
ey & Sons, Ltd.