Severe malaria in Togolese children.

Background - The definition of severe malaria is no longer limited to cereb ral malaria but is as well extended to other clinical forms of the disease. This work analyses epidemiological, clinical and evolutive aspects of seve re malaria in Togo. Patients and methods. - This study included 549 children, aged from 0 to 15 years, hospitalized in 1994-5 in the pediatric department of the Lome-Toko in University Teaching Hospital for severe malaria ar defined by World Heal th Organization (WHO) criteria. Results. - The hospitalization frequency was 7.44%; the maximum frequency w as from 1 to 5 years of age, but 6.56% of patients were more than 10 years old. The most frequent clinical form was that of severe anemia, followed by cerebral complications, as seen in many African countries. The death rate was 18.94% and the proportional mortality was 8.21%; 2.73% of the patients had neurological sequelae (behaviour disturbances in five cares, aphasia in four, hemiplegia in three, munchment in one oculomotor paralysis in one, a nd cerebellar ataxia in one). Hypoglycemia was fairly frequent (11.6%) and was associated with a poor prognosis. Conclusion. - It is possible to improve severe malaria prognosis in Africa by insisting not only on better equipment in intensive care wards, but also on improved and early management of hypoglycemia. (C) 1998 Elsevier, Paris .