A sister (aged 6 years) and brother (aged 8 years) presented four months ap
art with severe molluscum contagiosum. Both children demonstrated clinical
and laboratory evidence of combined immunodeficiency; The extent of skin in
volvement by molluscum contagiosum precluded conventional treatment as well
as intralesional interferon alpha (IFN alpha). Both subjects responded wel
l to subcutaneous IFN alpha.