Muscle strength in the elderly: Its relation to vitamin D metabolites

Objective: To identify a relation between loss of muscle strength and Vitam in D deficiency in ambulatory elderly persons not receiving vitamin D suppl ementation. Design: Cross-sectional study. Setting: All measurements were taken at the Department of Geriatrics, Unive rsity Hospital, Easel, Switzerland. Subjects: Three hundred nineteen patients (103 women, 216 men) selected by random sampling from participants in an ongoing interdisciplinary study on aging (mean age for women, 74.2yrs; for men, 76.7yrs). Outcome Measures: Leg extension power CLEF) and body mass index (BMI); seru m Values of 25-hydroxyvitamin D [calcidiol, 25(OH)D], 1,25-hydroxyvitamin D [calcitriol, 1,25(OH)(2)D], and intact parathyroid hormone (iPHT). Results: Twelve percent of women and 18% of men had 25(OH)D values below th e normal range (<12ng/mL). Muscle strength was lower in older subjects (fem ale: r = -.35; p = .0005/male: r = -.48;p < .0001) and was lower in women t han in men (p<.0001). In men both 25(OH)D and 1,25(OH)(2)D was significantl y correlated with LEP (r = 0.24; p = .0004/r = .14; p = .045). In women, on ly 1,25(OH)(2)D was significantly correlated with LEP (r = 0.22; p = .034). In an ANCOVA including all participants and explaining LEP by sex, age, BM I, 1,25(OH)(2)D, 25(OH)D, and iPTII, all factors showed significant effects except 25(OH)D and iPTH (r(2) = .41). Conclusion: Muscle strength declined with age in ambulatory elderly people and showed modest, but significant, positive correlation with 1,25(OH)(2) v itamin D in both sexes and with 25(OH)D in male subjects. Therefore vitamin D deficiency appears to contribute to the age-related loss of muscle stren gth, which might be more pronounced in institutionalized elderly people wit h a high prevalence of vitamin D deficiency. (C) 1999 by the American Congr ess of Rehabilitation Medicine and the American Academy of Physical Medicin e and Rehabilitation.