IS THERE A PROTECTIVE EFFECT OF PROTEIN-C IN EXPERIMENTAL MYOCARDIAL-INFARCTION IN RATS

Cardioprotective standard substances from different pharmacological cl asses as well as human plasma derived protein C and activated protein C were tested in a rat model of myocardial infarction (7 min occlusion , 20 min reperfusion) described by CROME et al. (1986). EGG-changes an d number of deaths were evaluated. The standard substances (two beta-a drenoceptor blocking drugs, one Typ I-antiarrhythmic drug and one so c alled calcium antagonist) improved EGG-signs of myocardial damage diff erently. Survival rate was increased but this was statistically not si gnificant. Protein C and activated protein C had little and equivocal effects on EGG-changes, there was a tendency to increased mortality. A cardioprotective effect of human (activated) protein C in rats was re futed based on these results. This is in good agreement with the findi ngs recently published by HAHN et al. (1996) using human recombinant, activated protein C in an analogous dog model of myocardial infarction .