Experience with allogeneic and syngeneic blood stem cell transplantation in patients with hematological malignancies

Citation
W. Rabitsch et al., Experience with allogeneic and syngeneic blood stem cell transplantation in patients with hematological malignancies, BONE MAR TR, 22, 1998, pp. S49-S52
Citations number
5
Categorie Soggetti
Hematology,"Medical Research Diagnosis & Treatment
Journal title
BONE MARROW TRANSPLANTATION
ISSN journal
02683369 → ACNP
Volume
22
Year of publication
1998
Supplement
4
Pages
S49 - S52
Database
ISI
SICI code
0268-3369(199812)22:<S49:EWAASB>2.0.ZU;2-5
Abstract
Between 1995 and 1997 twenty two patients with different hematological dise ases ( CML n=10, AML n=6, ALL n=1, NHL n=3, SAA n=1,solid tumor n=1) and a median age of 37 (range, 20 to 55) years received unmanipulated peripheral blood stem cell (PBSC) transplants from HLA-identical sibling donors at our institution. Myeloablative chemotherapy consisted of cyclophosphamide (CY) and total body irradiation in 11, and chemotherapy alone in 11 patients. F or graft-versus host-disease (GVHD) prophylaxis all patients were given cyc losporine A and methotrexate according to the Seattle protocol. PBSC were m obilized by granulocyte colony-stimulating factor (G-CSF) given at 10 mu g/ kg body weight (b.w.)/day for four days. Harvest of PBSC was started on day 5 and continued on day 6 if necessary. A median of 1 leukapheresis (range, 1 to 2) was performed and a median of 5.7 x 10(6).