Haemopoietic cell transplantation activity and results: a single institution experience

Between February 1993 and November 1997, 62 patients with severe aplastic a naemia (SAA), acute myeloid (AML), acute lymphoid (ALL), or chronic myeloid leukaemia (CML) as well as two patients with NHL underwent allogeneic marr ow transplantation (BMT) from HLA-identical or one-antigen mismatched sibli ng or unrelated donors; Patients received preparative regimens according to the baseline disease. Patients with SAA were conditioned with ATG/Cy (2 ca ses) and TAI/Cy (3 cases), AML, ALL and NHL with TBI/Cy (21 cases including two retransplantations) and CML with Mitobronitol/Ara-C/Cy except two pati ents conditioned traditionally with Bu/Cy. For GVHD prevention, patients re ceived cyclosporin-a (CsA) with short course methotheraxe according to the Seattle protocol. Significantly better overall survival rates were associat ed with the Mitobronitol (DBM)/Ara-C/Cy conditioning regarded the patients as a whole. Autologous stem cell transplantation (bone marrow and/or periph eral blood) were performed in ten cases including 2 AML, 4 non-Hodgkin's ly mphoma (NHL), 3 Hodgkin's disease (HD) and 1 patient with multiple myeloma (MM). Patients with AML and two patients with NHL were conditioned with TBI /Cy and the others with BEAM combined chemotherapy. Eight out of ten patien ts are leukaemia- or lymphoma-free survivors. One patient relapsed having c onventional chemotherapy and interferon maintenance therapy. One patient di ed in a rapid relapse five months post-BMT.