From September 1993 to August 1997, 24 consecutive adult acute leukemia pat
ients (20 AML and 4 ALL) received allogeneic bone marrow transplant (21 sib
ling, 1 twin, 2 MUD). The probability of 3 year leukemia free survival is 1
9/24 (79%), the transplant related mortality is 2/24(8%), the relapse rate
is 3/24 (13%), The median follow up period is 34 months (range 7-51), Three
AML patients with high probability of TRM received a special radiation-fre
e conditioning regimen (mitobronitol/cytarabine/cyclophosphamide) originall
y described by Kelemen ct al in CML patients for decreasing transplant rela
ted complications, All the three patients are alive and disease free over 3
years.