Acute skin GVHD following syngeneic BMT for CLL

A 41-year-old woman received a syngeneic BMT for CLL and subsequently devel oped acute skin GVHD, Transfusion-related allogeneic GVHD was excluded on t he basis of an unchanged HLA type in circulating lymphocytes, Short tandem repeat PCR was used to confirm syngeneicity between donor and recipient. Th e patient had a personal and family history of autoimmune disease which may have made her particularly susceptible to development of syngeneic GVHD. T he distinction between allogeneic and syngeneic or autologous GVHD is impor tant because of therapeutic implications.