Metoclopramide ameliorates the effects of endotoxin on gastric emptying ofacetaminophen in horses

The effect of metoclopramide on gastric emptying of a liquid marker in hors es was evaluated by measuring serum concentrations of acetaminophen, Gastri c emptying was determined in normal, fasted horses (n = 7), horses given en dotoxin intravenously (n = 7), and horses given intravenous metoclopramide plus endotoxin (n = 6), The mean time to reach maximum serum acetaminophen concentration (T-max), the maximum serum concentration (C-max), and the are a under the serum acetaminophen concentration vs time curve (AUC) were comp ared among treatment groups. Endotoxin caused a profound delay in gastric e mptying, and pretreatment with metoclopramide significantly (P < 0.05) amel iorated this effect.