J. Eisenberg et al., A COMPARISON OF PEAK SPUTUM TOBRAMYCIN CONCENTRATION IN PATIENTS WITHCYSTIC-FIBROSIS USING JET AND ULTRASONIC NEBULIZER SYSTEMS, Chest, 111(4), 1997, pp. 955-962
Study objective: To determine whether adequate concentrations of a new
formulation of tobramycin could be delivered to the lower respiratory
tract of patients with cystic fibrosis (CF) using a jet nebulizer del
ivery system. Design: A multicenter, open-label, randomized, crossover
study. Setting: Ten tertiary care, university-affiliated, teaching ho
spitals in the United States. Patients and control subjects: Sixty-eig
ht patients recruited from 10 CF Foundation centers and who were at le
ast 8 years of age, had a diagnosis of CF, and expectorated daily sput
um. No control subjects enrolled. Interventions: Each patient received
one administration of aerosolized tobramycin from each of the three n
ebulizer systems in random order. Each administration was separated by
a minimum of 48 h. The two jet nebulizer systems tested were the Side
stream (Medic-Aid; Sussex, UK), and the Pari LC (Pari Respiratory Equi
pment; Richmond, Va), with a DeVilbiss Pulmoaide compressor (DeVilbiss
Health Care; Somerset, Pa), both administering 300 mg tobramycin in 5
mL of 1/4 normal saline solution (NS), Patients were also administere
d 600 mg tobramycin in 30 mL of 1/2 NS with the UltraNeb 99/100 (DeVil
biss). Measurements: Sputum and serum tobramycin concentration and pul
monary function were monitored. An adequate peak sputum tobramycin con
centration was defined as > 128 mu g/g sputum at any of three time poi
nts (10, 60, or 120 min) after completion of treatments. Results: The
peak tobramycin concentrations in expectorated sputum were 687 +/- 663
mu g/g (mean +/- SD) with the Pari LC and 489 +/- 402 mu g/g with the
Sidestream. Adequate peak sputum tobramycin concentration was achieve
d in 93% of the patients with the Sidestream, and in 87% of the patien
ts with the Pari LC. Peak sputum concentrations were found to be subst
antially higher when patients received tobramycin administered with th
e UltraNeb 99/100, 1,498 +/- 1,331 mu g/g with 30% of patients having
levels exceeding 2,000 mu g/g. Serum tobramycin concentrations were le
ss than or equal to 4 mu g/mL for all patients following administratio
n with each nebulizer. Conclusions: Adequately high sputum tobramycin
concentrations were documented in sputum in >85% of patients following
the administration of 300 mg/5 mL formulation of tobramycin aerosoliz
ed by the two jet nebulizer delivery systems, Sidestream and Pari LC.
The single tobramycin administration delivered by these two systems is
well-tolerated.