Long-chain N-acylethanolamines inhibit lipid peroxidation in rat liver mitochondria under acute hypoxic hypoxia

Authors
Gulaya, NM Kuzmenko, AI Margitich, VM Govseeva, NM Melnichuk, SD Goridko, TM Zhukov, AD
Citation
Nm. Gulaya et al., Long-chain N-acylethanolamines inhibit lipid peroxidation in rat liver mitochondria under acute hypoxic hypoxia, CHEM PHYS L, 97(1), 1998, pp. 49-54
Citations number
24
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CHEMISTRY AND PHYSICS OF LIPIDS
ISSN journal
00093084 → ACNP
Volume
97
Issue
1
Year of publication
1998
Pages
49 - 54
Database
ISI
SICI code
0009-3084(199812)97:1<49:LNILPI>2.0.ZU;2-8
Abstract
Two long-chain N-acylethanolamines (NAEs:), N-palmitoyl- (NPE) and N-stearo ylethanolamine (NSE), are shown to inhibit an in vitro non-enzymatic Fe2+-i nduced free radical oxidation of lipids in the liver mitochondria of rats w ith hypoxic hypoxia. NSE appeared to be more effective than NPE in suppress ing some kinetic parameters of the Fe2+-induced chemiluminescence. The inhi bitory action of NAEs on non-enzymatic lipid peroxidation supports the idea that they possess membrane protective properties. (C) 1998 Published by El sevier Science Ireland Ltd. All rights reserved.