Glycosyl inositol derivatives related to inositolphosphoglycan mediators: Synthesis, structure, and biological activity

Some biologically active structures related to inositolphosphoglycan (IPG) mediators (compounds 3-5) and the corresponding glycosylphosphatidylinosito l precursors (compounds I and 2) have been prepared by using an effective s ynthetic strategy. The basic structural features of these substances have b een established by determining the solid-state structure of compound 3. the solution structure of compounds 3 a detergent micelle. The biological acti vity of some of these derivatives has also been investigated. It has been c onfirmed that compound 3 acts as potent mitogen in the chicken's developing inner ear and it has been demonstrated that 3 modulates the expression of Fos which is a molecular marker of cell proliferation.