In 1997, the National Heart, Lung, and Blood institute released the Second
Expert Panel Report on the Guidelines for the Diagnosis and Management of A
sthma as a follow-up to the first report issued in 1991, Implementation of
the recommendations from this report could have a potentially huge impact o
n care and treatment of asthma in the United States. Even though the Guidel
ines are expansive, there are some areas related to the pharmacologic compo
nent that warrant further discussion and clarification. These are: (1) safe
ty and efficacy of available asthma medications, (2) clinical efficacy comp
arisons of inhaled cortisosteroids, (3) comparative risks among inhaled cor
ticosteroids, and (4) expectations of different delivery systems used with
inhaled corticosteroids.