Streptococcal DNase B is immunologically identical to superantigen SpeF but involves separate domains

Authors
Eriksson, A Eriksson, B Holm, SE Norgren, M
Citation
A. Eriksson et al., Streptococcal DNase B is immunologically identical to superantigen SpeF but involves separate domains, CL DIAG LAB, 6(1), 1999, pp. 133-136
Citations number
23
Categorie Soggetti
Immunology
Journal title
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
ISSN journal
1071412X → ACNP
Volume
6
Issue
1
Year of publication
1999
Pages
133 - 136
Database
ISI
SICI code
1071-412X(199901)6:1<133:SDBIII>2.0.ZU;2-V
Abstract
The previous suggestion that streptococcal superantigen SpeF might be ident ical to DNase B was confirmed in this study. Polyclonal SpeF-specific antis era were able to inhibit depolymerization of methyl-green DNA by DNase B. H owever, T-cell mitogenicity and: nuclease activity appear to involve separa te immune epitopes on SpeF, since sera with the capacity to neutralize the mitogenic activity of SpeF did not always inhibit the DNase activity.