Microscale synthesis and screening of chiral stationary phases

An approach for the microscale synthesis and screening of combinatorial lib raries of chiral stationary phases (CSPs) is described. This technique offe rs a number of advantages over previously described methods for the prepara tion and evaluation of new CSPs: The stationary phases are made on 50 mg st ale or less and need not be packed into columns to be evaluated; a solid ph ase synthesis approach can be utilized to create diverse libraries of candi date CSPs; evaluation of the CSPs directly reveals the best CSP for a parti cular separation, consequently the screening results can be directly transl ated to chromatographic performance.