CONFIDENCE-INTERVALS FOR DIRECTLY STANDARDIZED RATES - A METHOD BASEDON THE GAMMA-DISTRIBUTION

We offer an approximation to central confidence intervals for directly standardized rates, where we assume that the rates are distributed as a weighted sum of independent Poisson random variables. Like a recent method proposed by Dobson, Kuulasmaa, Eberle and Scherer, our method gives exact intervals whenever the standard population is proportional to the study population. In cases where the two populations differ no n-proportionally, we show through simulation that our method is conser vative while other methods (the Dobson et al. method and the approxima te bootstrap confidence method) can be liberal. (C) 1997 by John Wiley & Sons, Ltd.