C-reactive protein: a cardiovascular risk factor - Report on the CRP hot-topic workshop October 1, 1997

On October 1, 1997, a 1 day hot-topic workshop on C-reactive protein (CRP) was organized in Leiden, the Netherlands, aiming at further evaluating the importance of inflammation as a critical mechanism in cardiovascular diseas e. C-reactive protein (CRP) is an acute phase protein that is associated with risk of cardiovascular events in healthy individuals and patients with angi na pectoris. At the workshop, several investigators who are the pioneers in studies on C RP as a cardiovascular risk factor presented the latest data and their view s on the topic. The discussions were designed to evaluate where we stand at present, and what should be done in the near future to promote evidence-ba sed diagnostics and evidence-based intervention/prevention strategies. The discussion focussed on the association between CRP and cardiovascular disea se (CVD), a possible causal role of CRP in CVD, the effect of drugs on CRP levels, the role of infectious agents in the relation between CRP and CVD, and the measurement of low levels of CRP. Although many questions remained, the meeting resulted in a better insight into the role of CRP in cardiovas cular disease and a basis for further studies in this area.