Yi. Ronin et al., Single- and multiple-trait mapping analysis of linked quantitative trait loci: Some asymptotic analytical approximations, GENETICS, 151(1), 1999, pp. 387-396
Estimating the resolution power of mapping analysis of linked quantitative
trait loci (QTL) remains a difficult problem, which has been previously add
ressed mainly by Monte Carlo simulations. The analytical method of evaluati
on of the expected LOD developed in this article spreads the "deterministic
sampling" approach for the case of two linked QTL for single- and two-trai
t analysis. Several complicated questions are addressed through this evalua
tion: the dependence of QTL detection power on the QTL effects, residual co
rrelation between the traits, and the effect of epistatic interaction betwe
en the QTL for one or both traits on expected LOD (ELOD), etc. Although thi
s method gives only an asymptotic estimation of ELOD, it allows one to get
all approximate assessment of a broad spectrum of mapping situations. A goo
d correspondence was found between the ELODs predicted by the model and LOD
values averaged ol er Monte Carlo simulations.