GASTRIC-CANCER ASSOCIATED GLYCOPROTEIN WITH BISECTION GLCNAC STRUCTURE

In this report, the clinical significance of gastrointestinal cancer a ssociated glycoprotein with bisection GlcNAc structure was investigate d by affinity assay and immunobiochemical methods. The results of 51 C r-release assay suggested that this glycoprotein could inhibit the cyt otoxicity of NK and LAK cells for their target cells. The results of e nzyme-linked immunoassay suggested that the expression of gastric canc er associated glycoproteins with bisection GlcNAc oligosaccharides str ucture was higher in serum of the patient with gastrointestinal cancer than that in serum of the patient with benign disease. (p<0.001). The sensitivity of this analysis procedure were 59.9% (191/320) for diagn osis of gastric cancer and 64.1% (100/156) for diagnosis of colorectal cancer. Its speciality was 91.8% for diagnosis of tumor. The results also indicated that the level of gastric cancer oligosaccharides in se rum related to the differentiation type of cancer and the immunologica l activity of LAK cells. The present study provided a new approach for research on tumor marker and glycosylation associated with gastro-int estinal cancer.