Synthesis of some new 3-(fluorophenyl) isocoumarins and their conversion to (dl)-3,4-dihydroisocoumarins

Authors
Hussain, MT Rama, NH
Citation
Mt. Hussain et Nh. Rama, Synthesis of some new 3-(fluorophenyl) isocoumarins and their conversion to (dl)-3,4-dihydroisocoumarins, I J HET CHE, 8(2), 1998, pp. 99-102
Citations number
4
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
09711627 → ACNP
Volume
8
Issue
2
Year of publication
1998
Pages
99 - 102
Database
ISI
SICI code
0971-1627(199810/12)8:2<99:SOSN3I>2.0.ZU;2-L
Abstract
3-(Fluorophenyl) isocoumarins (6a-c) were synthesized by the condensation o f homophthalic acid (4) with fluorobenzoyl chlorides (5a-c) which on alkali ne hydrolysis gave keto-acids (7a-c). (dl)-3-(Fluorophenyl)-3,4-dihydroisoc oumarins (10a-c) were obtained by reduction of keto-acids (7a-c) to racemic hydroxy-acids (9a-c) followed by cyclodehydration using acetic anhydride.