Asymptomatic hyponatremia due to inappropriate secretion of antidiuretic hormone as the first sign of a small cell lung cancer in an elderly man

Citation
K. Kamoi et al., Asymptomatic hyponatremia due to inappropriate secretion of antidiuretic hormone as the first sign of a small cell lung cancer in an elderly man, INTERN MED, 37(11), 1998, pp. 950-954
Citations number
16
Categorie Soggetti
General & Internal Medicine
Journal title
INTERNAL MEDICINE
ISSN journal
09182918 → ACNP
Volume
37
Issue
11
Year of publication
1998
Pages
950 - 954
Database
ISI
SICI code
0918-2918(199811)37:11<950:AHDTIS>2.0.ZU;2-W
Abstract
A 72-year-old man was hospitalized with asymptomatic hyponatremia, Despite hyponatremia, urinary sodium excretion with urine osmolality exceeding plas ma osmolality persisted. Plasma vasopressin levels were high and independen t of plasma osmolality during hypertonic saline infusion. Computed tomograp hy of the chest showed enlarged mediastinal and right hilar lymph nodes. Mi croscopically, a specimen of lymph nodes obtained by biopsy represented vas opressin-producing small cell lung carcinoma. Chemotherapy plus irradiation improved the hyponatremia, Thus, careful evaluation is necessary to determ ine the cause of hyponatremia disorders in elderly patients.