CONTINUOUS PRODUCTION OF DICARBOXYLIC-ACID BY IMMOBILIZED PSEUDOMONAS-AERUGINOSA CELLS

Treatment of Pseudomonas aeruginosa with 3% (v/v) Tween 80 resulted in a 16-fold increase in the yield of conversion of n-pentadecane to the corresponding dioic acid, tridecane 1,13-dicarboxylic acid (DC-15). H owever, this conversion process was inhibited by high concentrations o f DC-15. To avoid this product inhibition, a continuous process with i mmobilized cells was performed, and the results showed that the DC-15 yield was four-fold higher than in the case of batch type DC-15 produc tion. The continuous process used in this study is adaptable to large- scale production of DC-15.