This contribution gives paradigms for static and dynamic effectors of micro
bial cultures. Macroscopic and physiological steady states are differentiat
ed. The examples comprise: inhibitory and regulatory effects of medium comp
onents affecting growth and product formation. possible pitfalls in trying
to speed-up operational procedures, responses to foam Formation and supply
of alternate carbon or oxygen sources, and cell cycle dependent events. (C)
1998 Elsevier Science B.V. All rights reserved.