Since it was first described in 1974, endoscopic sphincterotomy has been th
e procedure of choice for management of choledocholithiasis, especially for
retained common bile duct stones. However, it has the dubious distinction
of being the most hazardous of all endoscopic retrograde cholangiopancreato
graphic procedures and carries an immediate complication rate of 8-10%. Con
cern has also been voiced about the long-term complications of sphincteroto
my, as the sphincter of Oddi is cut during the procedure. To prevent, or at
least lessen, the short- and long-term complications of endoscopic sphinct
erotomy, an alternative in the form of balloon dilatation of the papilla, h
as been advocated. However, the procedure of balloon dilatation is cumberso
me, time consuming and, more importantly, a recent multi-centre study from
the US comparing endoscopic sphincterotomy with balloon dilatation observed
higher complications with balloon dilatation. The use of nitrites to relax
the papilla is another novel method used for removal of common bile duct c
alculi. So how should a therapeutic endoscopist decide which method is to b
e used? The advantage of endoscopic sphineterotomy is that it has been arou
nd for more than two decades and most endoscopists are familiar with the te
chnique as well as its complications. It can be accomplished quickly and wi
th the advent of wire-guided and balloon-mounted sphincterotomes, the time
taken for the procedure to be completed has been reduced further. The compl
ications of the procedure are less when it is employed for removal of commo
n bile duct stones and when used by experts. It, therefore, still appears t
o be the procedure of choice for endoscopic management of choledocholithias
is. The other two methods may, however, be useful in patients with coagulop
athy.