Synthesis of 4-aryl-2,3,6,7-tetrahydro-1H-pyrimido[4,5-b][1,4]-diazepin-6-ones from 4,5-diamino-1H-pyrimidin-6-ones and 1-aryl-3-(dimethylamino)-1-propanones

Authors
Insuasty, B Argoti, JC Gomez, S Quiroga, J Martinez, R Angeles, E Gabino, R Nogueras, M Sanchez, A
Citation
B. Insuasty et al., Synthesis of 4-aryl-2,3,6,7-tetrahydro-1H-pyrimido[4,5-b][1,4]-diazepin-6-ones from 4,5-diamino-1H-pyrimidin-6-ones and 1-aryl-3-(dimethylamino)-1-propanones, J HETERO CH, 35(6), 1998, pp. 1397-1399
Citations number
19
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
0022152X → ACNP
Volume
35
Issue
6
Year of publication
1998
Pages
1397 - 1399
Database
ISI
SICI code
0022-152X(199811/12)35:6<1397:SO4>2.0.ZU;2-#
Abstract
The reaction of 1-aryl-3-(dimethylamino)-1-propanones 1 with one equivalent of 4,5-diamino-1H-pyrimidin-6-ones 2, in acidic medium, leads to the forma tion of 4-aryl-2,3,6;7-tetrahydro-1H-pyrimido[4,5-b]-[1,4]diazepin-6-ones 3 . The structure elucidation of the products is based on detail nmr analysis of experiments such as C-13, H-1 and DEFT including selective C-13{H-1} de coupling experiments.