Pyridazines. XV. Synthesis of 6-aryl-5-amino-3(2H)-pyridazinones as potential platelet aggregation inhibitors

Authors
Estevez, I Ravina, E Sotelo, E
Citation
I. Estevez et al., Pyridazines. XV. Synthesis of 6-aryl-5-amino-3(2H)-pyridazinones as potential platelet aggregation inhibitors, J HETERO CH, 35(6), 1998, pp. 1421-1428
Citations number
30
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
0022152X → ACNP
Volume
35
Issue
6
Year of publication
1998
Pages
1421 - 1428
Database
ISI
SICI code
0022-152X(199811/12)35:6<1421:PXSO6A>2.0.ZU;2-#
Abstract
Several 3(2H)-pyridazinones with amino groups at the 5-position of the pyri dazine nucleus have been prepared. The 6-aryl-5-halo-3(2H)-pyridazinones ob tained from mucochloric and mucobromic acid lead to the corresponding 5-alk ylamino-3(2H)-pyridazinones, which were tested as platelet aggregation inhi bitors.