Microbial hydroxylation of 2-oxatestosterone

Authors
Holland, HL Lakshmaiah, G
Citation
Hl. Holland et G. Lakshmaiah, Microbial hydroxylation of 2-oxatestosterone, J MOL CAT B, 6(1-2), 1999, pp. 83-88
Citations number
28
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
ISSN journal
13811177 → ACNP
Volume
6
Issue
1-2
Year of publication
1999
Pages
83 - 88
Database
ISI
SICI code
1381-1177(19990104)6:1-2<83:MHO2>2.0.ZU;2-W
Abstract
An investigation has been undertaken of the microbial biotransformation of 2-oxatestosterone by microorganisms known to hydroxylate conventional stero ids, using Aspergillus ochraceus, Bacillus megaterium, Curvularia lunata an d Rhizopus arrhizus. A. ochraceus and B. megaterium gave products of 11 alp ha- and 15 beta-hydroxylation, respectively. Biotransformation by C. lunata gave C-11 beta- and C-14 alpha-hydroxylated products, whereas R. arrhizus produced only the 6 beta-hydroxy derivative. (C) 1999 Elsevier Science B.V. All rights reserved.