Long-term functional outcome of suprasellar germinomas: Usefulness and limitations of radiotherapy

We investigated the long-term functional outcome of patients with suprasell ar germinoma after radiotherapy to determine the usefulness and limitations of radiotherapy for these tumors. From among 54 cases of intracranial germ cell tumor at Kitasato University Hospital, 12 patients with suprasellar g erminoma who were treated with radiotherapy but not chemotherapy retrospect ively investigated for mental, hormonal and visual functions. The follow-up period ranged from 63 to 262 months (mean, 161.1 months). The mortality ra te was zero and there was no recurrence of tumors. However, three patients treated with local irradiation alone showed metastasis to the ventricles or spinal cord. With regard to mental function, 50% of the patients showed re markably low mental function after radiotherapy. With regard to pituitary h ormonal function, deficiency of ADH, GH, ACTH, and TSH was documented in 75 %, 41.7%, 16.7% and 8.3% of the patients, respectively, before radiotherapy . Prolactin was elevated in 50% of the patients. After radiotherapy, 91.7% needed hormone replacement. With regard to visual function, most patients s howed an improvement or no change after radiotheray. In conclusion, radioth erapy for suprasellar germinomas gave long-time survival. However, such rad iotherapy may cause mental and pituitary hormonal dysfunction. Our results show that while radiotherapy is useful for treating suprasellar germinomas, its dose have some limitations.