S. Mathison et E. Bakker, Improving measurement stability and reproducibility of potentiometric sensors for polyions such as heparin, J PHARM B, 19(1-2), 1999, pp. 163-173
The growing importance of polymer membrane-based potentiometric polyion sen
sors in biomedical research and clinical measurements has brought up the qu
estion of how accurate and reproducible these sensors are. Indeed, recent r
esearch has revealed that these sensors behave quite differently than class
ical ion-selective electrodes. This paper explores ways to improve measurem
ent reproducibility and long term potential stability by considering the un
ique pseudo steady-state response mechanism of the polyion sensors develope
d so far. Heparin may be stripped out of the phase boundary membrane surfac
e with a high sample NaCl concentration and this characteristic is used to
modify the calibration procedure in order to avoid memory effects. It is al
so attempted to reduce long term potential drifts by continuously stripping
heparin out of the membrane at the membrane-inner filling solution side. (
C) 1999 Elsevier Science B.V. All rights reserved.