Fluorimetric and solubility studies of nadolol and atenolol in SDS micelles

The effect of sodium dodecyl sulfate (SDS) micelles on the spectrofluorimet ric intensities and on the solubility of two beta-blockers (atenolol and na dolol) were studied at 25.0 +/- 0.1 degrees C and I = 0.1 M NaCl. From the dependence of these physical properties on SDS concentration it was possibl e to calculate the binding constants drug-micelle, and it was found that bo th techniques yield similar results for the binding constants, and that are in agreement with those calculated from the effect of micelles on the appa rent acidity constants of the beta-blockers. (C) 1998 Elsevier Science B.V. All rights reserved.