For the Matsigenka of the Peruvian Amazon, health and well-being in daily l
ife depend upon harmonious relationships within the social group and with t
he spirit world. Psychoactive plants play a crucial role in curing disrupte
d social relationships while giving humans access to the otherwise remote,
parallel world of spirits. Different species and cultivars of psychoactive
plants, as well as varying admixtures and doses, are used to obtain differe
nt intensities and qualities of psychoactive experience, depending upon the
individual's goals. Strongly psychoactive plants are used by shamans to tr
avel to the realm of spirits. A number of mild to strongly psychoactive pla
nts are used by male hunters to purify their souls and improve their aim. M
ildly psychoactive plants are used to improve women's concentration for spi
nning and weaving cotton, to control negative emotions such as grief and an
ger, to manipulate the content of dreams, and to pacify sick or frightened
children. A majority of such remedies come from the botanical families of R
ubiaceae, Solanaceae and Cyperaceae, known sources of psychoactive compound
s. Interdisciplinary research into the culture, botany and pharmacology of
psychoactive plants in indigenous medical systems contributes to a better u
nderstanding of the role of psychological states in human health and well-b
eing.