Ih. Hall et al., THE CYTOTOXICITY OF HYLPHENYL)SULFONYL]-1,4,7,10-TETRAAZACYCLODODECANE IN HUMAN TMOLT(3) T-LEUKEMIC-CELLS, Anticancer research, 17(2A), 1997, pp. 1195-1198
yl)-4,7,10-tris-[(4'methylphenyl)-sulfonyl]-1,4,7, 10-tetraazacyclodod
ecane proved to possess potent in vivo antineoplastic and in vitro cyt
otoxicity in murine and human tissue cultured cells. In Tmolt3 leukemi
c cells hylphenyl)sulfonyl]-1,4,7,10-tetraazacyclododecane inhibited t
he activities of the regulatory enzymes of the purine pathway leading
to significant reductions in both RNA and DNA synthesis. Other sites o
f action of the compound which led to reductions of nucleic acid synth
esis were suppression of nucleoside kinase and thymidylate synthetase
activities and reductions in the d[NTP] pool levels. DNA fragmentation
occurred which should be linked directly with cancer cell death.