THE CYTOTOXICITY OF HYLPHENYL)SULFONYL]-1,4,7,10-TETRAAZACYCLODODECANE IN HUMAN TMOLT(3) T-LEUKEMIC-CELLS

yl)-4,7,10-tris-[(4'methylphenyl)-sulfonyl]-1,4,7, 10-tetraazacyclodod ecane proved to possess potent in vivo antineoplastic and in vitro cyt otoxicity in murine and human tissue cultured cells. In Tmolt3 leukemi c cells hylphenyl)sulfonyl]-1,4,7,10-tetraazacyclododecane inhibited t he activities of the regulatory enzymes of the purine pathway leading to significant reductions in both RNA and DNA synthesis. Other sites o f action of the compound which led to reductions of nucleic acid synth esis were suppression of nucleoside kinase and thymidylate synthetase activities and reductions in the d[NTP] pool levels. DNA fragmentation occurred which should be linked directly with cancer cell death.