Effect of colchicine in the subcorneal pustular dermatosis type of IgA pemphigus

Background: IgA pemphigus of the subcorneal pustular dermatosis (SPD) type is characterized by subcorneal acantholysis and by an abundance of neutroph ils, making colchicine a reasonable pharmacologic option for treatment. Objective: We attempted to determine the efficacy of colchicine in the trea tment of SPD-type IgA pemphigus. Methods: Two patients with SPD-type IgA pemphigus were treated with colchic ine 1.5 mg/day as monotherapy. Results: A sustained clinical response was a chieved within 2 to 3 weeks of therapy. Relapses were noted each time colch icine was stopped. Conclusion: Colchicine should be considered in the treatment of SPD-type Ig A pemphigus.