Purpose: Previously, we have shown that Spatially Varying Bayesian Ima
ge Estimation (SVBIE) can be used to reduce scatter and improve contra
st-to-noise ratios (CNR) in digital chest radiographs with no degradat
ion of image resolution. This previous algorithm used a model for scat
ter compensation that was derived for emission tomography. Here, we de
velop and evaluate a new iterative SVBIE technique that incorporates a
scatter model derived for projection radiography. Materials and Metho
ds: Portable digital radiographs of an anthropomorphic chest phantom w
ere obtained along with quantitative scatter measurements using a cali
brated photostimulable phosphor system. The new iterative SVBIE techni
que was applied to the phantom image to reduce scatter. Scatter fracti
on reduction, CNR improvement, and resolution degradation were evaluat
ed. Results: Residual scatter fractions were reduced to less than 2% i
n the lungs and 30% in the mediastinum at 14 iterations. CNR was impro
ved by approximately 50% in the lung region and 187% in the mediastinu
m. Resolution was not degraded. Conclusions: The new SVBIE technique c
an reduce scatter to levels far below those provided by an antiscatter
grid and can increase CNR without loss of resolution. The new techniq
ue outperforms the previous Bayesian techniques. (C) 1997 American Ass
ociation of Physicists in Medicine.