Induction of B-cell lymphoma in BALB/c nude mice with an ecotropic, B-tropic helper virus present in the murine AIDS virus stock

Authors
Tayar, L Higo, K Kubo, Y Wang, Y Lu, LM Zhang, FM Iwatani, Y Wang, L Ono, T Maeda, M Sakai, H Ishimoto, A
Citation
L. Tayar et al., Induction of B-cell lymphoma in BALB/c nude mice with an ecotropic, B-tropic helper virus present in the murine AIDS virus stock, J VIROLOGY, 73(2), 1999, pp. 1640-1644
Citations number
22
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
73
Issue
2
Year of publication
1999
Pages
1640 - 1644
Database
ISI
SICI code
0022-538X(199902)73:2<1640:IOBLIB>2.0.ZU;2-X
Abstract
The pathogenicities of the murine AIDS (MAIDS) virus complex (LP-BM5) and e cotropic helper virus (BM5eco) isolated from the complex to BALB/c nude mic e were studied to elucidate the possible role of replication-competent help er virus in inducing the monoclonal outgrowth of lymphoid cells. Neither LP -BM5 nor BM5eco was pathogenic in adult BALB/c nude mice. However, B-cell l ymphoma developed with a very high frequency when either virus was inoculat ed into newborn BALB/c nude (nu/nu) mice. The cells from the B-cell lymphom a were easily transplanted into nude mice. These results suggested that eco tropic helper virus in the MAIDS virus complex plays an important role in i nducing the monoclonal outgrowth of lymphoid cells under immunodeficient co nditions caused by defective virus.