Distinct recognition of non-clade B human immunodeficiency virus type 1 epitopes by cytotoxic T lymphocytes generated from donors infected in Africa

Authors
Dorrell, L Dong, T Ogg, GS Lister, S McAdam, S Rostron, T Conlon, C McMichael, AJ Rowland-Jones, SL
Citation
L. Dorrell et al., Distinct recognition of non-clade B human immunodeficiency virus type 1 epitopes by cytotoxic T lymphocytes generated from donors infected in Africa, J VIROLOGY, 73(2), 1999, pp. 1708-1714
Citations number
32
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
73
Issue
2
Year of publication
1999
Pages
1708 - 1714
Database
ISI
SICI code
0022-538X(199902)73:2<1708:DRONBH>2.0.ZU;2-2
Abstract
We present detailed studies of human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte (CTE) responses to clade A or C HIV type 1 in three donors infected in East Africa. We define several novel non-clade B CTL epi topes, including some restricted by HLA alleles common in Africans. Althoug h cross-clade CTL recognition of these epitopes does occur, recognition can also be highly clade specific.